England will be without Manu Tuilagi for their Six Nations clash with Wales after the centre suffered a hamstring injury.

Tuilagi had been set to return from an injury lay off to feature at Twickenham on Saturday, having been named in the team that Eddie Jones confirmed on Thursday.

However, England have been dealt a blow as scans after training revealed a hamstring problem for the 30-year-old.

England have recalled Joe Marchant, who will train with the squad on Friday. However, an updated team will not be confirmed until the day of the game.

Tuilagi had been set to play alongside Henry Slade in midfield for Jones' team, who bounced back from their defeat to Scotland in the opening match by beating Italy last time out.

He has represented England in 46 Tests so far since making his debut in 2011.

Manu Tuilagi and captain Courtney Lawes will make their returns from injury in England's Six Nations showdown with Wales at Twickenham, while forward Taulupe Faletau will make his first appearance since last year's competition for the visitors on Saturday.

Both sides have posted a win and a loss in their two games so far to trail early leaders France in the table.

England bounced back from a 20-17 loss to Scotland by thrashing Italy 33-0 last time out, while Wales beat Scotland 20-17 after opening their title defence with a 29-7 defeat in Ireland.

Lawes returns from a concussion-enforced layoff which has kept him out of action since January, and regains the captaincy he held against South Africa last Autumn, replacing stand-in Tom Curry in the role.

Tuilagi also makes a welcome return from injury, but Ben Youngs will have to wait to win a record 115th cap after being named on the bench, as Eddie Jones makes four changes to the team which impressed in Rome, with Luke Cowan-Dickie and Kyle Sinckler also coming in.

Looking ahead to the match, Jones told England Rugby that he was content with his side's preparation, and was excited ahead of the showdown.

"We've prepared very well for this game, the squad have really come together on and off the pitch," said Jones. 

"Wales are a good, tough side and Six Nations champions, and it will make for an exciting Test match in front of a full Twickenham crowd.

"We've got a talented, young, hungry squad who have trained with real intensity this week. We're ready to go at them and can't wait to play in front of our supporters again."

Courtney Lawes and Manu Tuilagi could make a welcome return for England in their Six Nations showdown with Wales at Twickenham.

Lawes may have been installed as England skipper for the tournament if he had not been sidelined due to concussion.

The towering lock missed the loss to Scotland and a win over Italy, but head coach Eddie Jones is hopeful he can face defending champions Wales a week on Saturday.

Centre Tuilagi could also be unleashed on Wayne Pivac's side, having been back in action for Sale Sharks after recovering from a hamstring injury.

Lock Joe Launchbury (knee) and flanker Lewis Ludlam (ribs) could also be back in contention. 

"Potentially we'll have Launchbury, Tuilagi, Lawes and Ludlam," Jones said.

Tom Curry has captained England in the absence of the injured Owen Farrell and Lawes.

But Lawes could have the honour of leading the Red Rose out once again in a battle between two sides who have won one and lost one of their matches heading into a weekend off.

The Australian added: "We'd be hopeful that by the end of next week Courtney will be training fully.

"He's making some great progress and the medical staff have done some terrific work with him. He's not far away now and we're really hopeful he'll be back in full training and able to play against Wales."

Jones said of Tuilagi: "Just having a power running centre would give us a different option.

"Everything we're doing now is about trying to create opportunities through finesse and that's through good running lines and passing.

"But to have someone who can take you forward quickly and engage two or three defenders then allows you to try and finesse extra space, which would be really useful to us.

"We've had three centres play and I think Sladey [Henry Slade] has been very good. Joe Marchant and Elliot Daly have had their moments, but we need to get more out of that and we understand that."

Manu Tuilagi could be fit for England's second match of the Six Nations against Italy at Stadio Olimpico.

The Sale Sharks centre has been sidelined since suffering a torn hamstring when he scored a try in the Red Rose's win over South Africa at Twickenham in November.

Tuilagi is on course to make his return for Sale against Harlequins in the Premiership a week on Sunday, the day after England face Scotland in their Six Nations opener at Murrayfield.

And Sharks director of rugby Alex Sanderson says the 30-year-old powerhouse may be back in international action in Rome on February 13.

"Harlequins is the projected return, and then we will see how he feels for Six Nations," said Sanderson.

"It is a week-to-week thing for Manu, but England have total autonomy over when he plays and doesn't play, and if he looks really good and feels good, he will go straight through to England and it could be Italy."

Sanderson revealed a clash with his former club Leicester Tigers this Sunday came too soon for Tuilagi.

"He is training and looking good, but we think it is too much of a risk to push him this weekend," Sanderson added.

"He is an exceptional trainer and a quick healer, so all of his progressions are done on the back of hitting physiological markers and GPS speeds, re-scans and seeing the specialist, and we would never push him earlier."

England this week suffered a blow when captain Owen Farrell was ruled out of the Six Nations due to an ankle injury.

Marcus Smith starts at fly-half and Owen Farrell returns at inside centre, while Manu Tuilagi moves to the wing when England face Australia on Saturday.

Smith came off the bench in the 69-3 thrashing of Tonga last weekend but will make his third Test start in place of George Furbank against the Wallabies at Twickenham.

Captain Farrell comes back into the team after missing the drubbing of the Pacific island nation due to his positive coronavirus test.

Tuilagi shifts from midfield to the right wing, with Jonny May on the other flank, and Maro Itoje will make his 50th appearance for his country in an unchanged pack.

Bevan Rodd and Raffi Quirke could make their debuts off the bench, but Joe Marler will not feature after the prop tested positive for COVID-19.

England head coach Eddie Jones said: "We know this will be a tough test for us, we're playing against a team who have been together a while and who have beat the world champions twice. As an Australian, I know how much this game means.

"We've had a really good week of preparation, we're looking to improve our performance this week and I think this side is building well."

England: Freddie Steward, Manu Tuilagi, Henry Slade, Owen Farrell (captain), Jonny May, Marcus Smith, Ben Youngs; Ellis Genge, Jamie George, Kyle Sinckler, Maro Itoje, Jonny Hill, Courtney Lawes, Sam Underhill, Tom Curry.

Replacements: Jamie Blamire, Bevan Rodd, Will Stuart, Charlie Ewels, Alex Dombrandt, Sam Simmonds, Raffi Quirke, Max Malins.

Fraser Dingwall has been called up to the England squad in place of Manu Tuilagi, who has withdrawn due to injury.

The Sale Sharks centre was hurt during his side's 40-30 Premiership semi-final defeat to Exeter Chiefs last Saturday.

Tuilagi, who missed the autumn internationals last year and England's Six Nations campaign, was only three games into a return following an Achilles problem sustained last September.

Northampton Saints' Dingwall has joined up with Eddie Jones' squad ahead of the match between England A and Scotland A in Leicester on Sunday.

Jones' men then play a Test match double-header against the United States at Twickenham on July 4 and July 10.

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