David Ospina made two saves in the penalty shoot-out to lift Colombia past Uruguay and into the Copa America semi-finals on Saturday.

After both sides went scoreless in normal time, Los Cafeteros converted on all four of their penalties while veteran Ospina saved attempts from Jose Gimenez and Matias Vina.

That left Colombia to celebrate their triumph in a hard-fought, physical encounter in Brasilia after Los Cafeteros had struggled into the quarter-finals.

Uruguay entered the quarter-finals having won two games in a row, while Colombia had been defeated in their final two group-stage games.

After waiting 10 days since their last game, Colombia looked the more energetic side in the opening half, out-shooting Uruguay 4-1 but Fernando Muslera had little to do in the Uruguay net.

Luis Muriel fired wide on an open look just prior to half-time, minutes after sending a free kick from a dangerous spot over.

Colombia's momentum carried over to the second half, as Luis Diaz drove straight to the Uruguay goal in the opening seconds but could not get a clear look.

Uruguay's first dangerous chance came in the 50th minute, when Nahitan Nandez curled a ball in from the right side that caught Ospina off-balance, but the goalkeeper acrobatically tipped the ball away from the top corner.

Colombia came close in the 73rd minute as Rafael Borre's cross from the right side found Duvan Zapata, but Muslera parried away the header from eight yards.

Both sides charged forward at every opportunity in the final 15 minutes but neither came close to scoring as Colombia kept Luis Suarez and Edinson Cavani at bay throughout.

It was the fourth consecutive Copa America quarter-final for Colombia in which the game was scoreless in regulation.

Real Madrid booked their place in the Champions League quarter-finals after a 3-1 win over Atalanta on Tuesday thanks to goals from Karim Benzema, Sergio Ramos and Marco Asensio.

With a 1-0 lead from the first leg, Benzema eased any nerves for Madrid when he swept home in the first half following a mistake by Atalanta goalkeeper Marco Sportiello.

Madrid were awarded a penalty after the break when Vinicius Junior was clumsily fouled by Rafael Toloi and Ramos emphatically buried the resulting spot-kick.

Atalanta pulled a late goal back with a free-kick from Luis Muriel, but Asensio ensured there was no drama with goal on the counterattack.

Madrid made a tentative start and Atalanta went close early on when Muriel cut the ball back for Robin Gosens, who could only manage a tame shot straight at Thibaut Courtois.

Los Blancos eventually found their rhythm midway through the half when the lively Vinicius combined with Benzema inside the box, but the Brazilian saw his goal-bound effort blocked.

Zinedine Zidane's side took the lead after a weak clearance by Sportiello went straight to Luka Modric and he fed Benzema, who finished clinically.

Vinicius almost added a second in spectacular fashion, shooting wide with just Sportiello to beat after a dazzling run.

Ramos left Atalanta with a mountain to climb when he converted from the spot, Sportiello unable to keep it out despite getting a hand to the ball.

Benzema headed against the post and Courtois twice saved from Duvan Zapata before Atalanta pulled one back – Muriel curling a superb free-kick into the top-right corner with seven minutes left.

Madrid finished the game with a flourish and a minute later Asensio punished the Serie A outfit on the counterattack, beating Sportiello at his near post.

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