Daniil Medvedev was defeated on his ATP Tour return at the Geneva Open by a sparkling Richard Gasquet, a blow to the Russian ahead of the French Open

World number two Medvedev was making his first appearance since March after undergoing a hernia operation and fell to a 6-2 7-6 (7-5) defeat.

The Russian's rustiness was clear in the last-16 tussle as he racked up seven double faults and struggled to make inroads on Gasquet's second serve, with the Frenchman winning 61 per cent of points behind it.

It was the first time Gasquet overcame an opponent ranked in the top two since beating Roger Federer at the 2005 Monte Carlo Masters.

Next up for Gasquet will be Kamil Majchrzak, who beat Marco Cecchinato 6-2 6-3.

At the last-32 stage, Fabio Fognini went down 6-4 6-3 to Thanasi Kokkinakis and Albert Ramos-Vinolas succumbed to a 7-6 (7-5) 6-4 loss against Christopher O'Connell.

Johan Nikles, Nikoloz Basilashvili and Joao Sousa also advanced to the second round.

Top seed Cameron Norrie cruised into the quarter-finals of the Lyon Open by beating Francisco Cerundolo 6-4 6-4.

The Briton will face another Argentinian next in the form of Sebastian Baez, who came from a set down to beat Oscar Otte 5-7 6-4 6-2. 

Alex De Minaur also had to rally for a 1-6 6-3 6-2 win against Ugo Humbert, with Yosuke Watanuki awaiting in the last eight after the world number 263 beat Soonwoo Kwon 6-3 6-4.

Stan Wawrinka said he was "feeling great" after securing his first win in 15 months by downing 14th seed Reilly Opelka at the Internazionali d'Italia.

The three-time grand slam winner made his tour return last month after requiring two surgeries on a left foot injury, but rallied after losing his first set against Opelka to secure a memorable 3-6 7-5 6-2 first-round victory.

Speaking after booking a second-round meeting with Laslo Djere, who beat Borna Coric 6-2 6-7 (3-7) 6-2, Wawrinka said his desire to play at the top level never left him, despite his injury woes.

"I think in general I was feeling good on the court, physically I was feeling great," he said. "For sure, when you don't win a match in more than a year, you start to think about it more than you should and not focus on the right things. 

"In general, I think it was a great match, a great battle. I stayed positive. I started to feel much better with my tennis by the end of the second set, and in the third set. I'm really happy with this victory.

"After two surgeries, at my age I could easily have stopped playing because my career is way better than what I expected when I was young.

"But I still have this fire in me. I still believe that I can play great tennis. I still believe that I make some big results, maybe not now, but in a few months."

Fellow former grand slam champion Dominic Thiem, who also returned from a long injury-enforced absence last month, fared less well, going down in straight sets to Fabio Fognini.

Having lost to Andy Murray at the Madrid Open last time out, 2020 US Open winner Thiem is still chasing his first victory of the year after losing 6-4 7-6 (7-5) to the 34-year-old Italian.

Elsewhere, 13th seed Denis Shapovalov edged an epic three-hour contest against Italy's Lorenzo Sonego 7-6 (7-5) 3-6 6-3, responding after being handed a game penalty for shouting expletives at a partisan crowd in Rome during the second set.

The frustrated Canadian was heard to tell spectators: "Shut the f*** up" when being booed after complaining about a second serve being called out by the umpire, but eventually regained his composure to claim a three-set win.

Shapovalov will face Georgia's world number 25 Nikoloz Basilashvili in the second round after he overcame Daniel Evans 7-6 (7-2) 6-2, while the only other seed to play on Monday, Spain's Pablo Carreno Busta, cruised to a 6-3 6-2 victory over Federico Delbonis.

Andy Murray swept aside Dominic Thiem in impressive fashion to secure his first clay-court win in five years as the Scot advanced to the second round at the Madrid Open on Monday.

The three-time grand slam champion was largely in control against his Austrian opponent, hitting nine aces and saving all three break points against his serve, while Thiem could only save one of the three he faced as Murray won 6-3 6-4.

He will now play 14th seed Denis Shapovalov after the Canadian beat Ugo Humbert 7-6 (7-1) 6-3.

The winner of that contest will have a last-16 meeting against the victor of Novak Djokovic and Gael Monfils after the latter eased into the round of 32 to set up a clash with the Serbian.

Monfils defeated wildcard Carlos Gimeno Valero 6-3 6-0 in less than an hour, while Alejandro Davidovich Fokina also advanced with a 7-5 6-3 win against Lloyd Harris.

Dusan Lajovic set up a second-round match against fifth seed Casper Ruud, who defeated Borna Coric 6-3 4-6 6-4, and ninth seed Cameron Norrie will go up against John Isner, the Briton having overcome Soonwoo Kwon 7-5 7-5.

An interesting tie awaits the much-talked about Carlos Alcaraz after Nikoloz Basilashvili beat Fabio Fognini 7-5 6-4, with the Georgian to face the number seven seeded teenager next.

Jannik Sinner, the 10th seed, scraped through a hard-fought encounter against American Tommy Paul 6-7 (4-7) 7-6 (7-4) 6-3, and will play Alex de Minaur next after the Australian beat Pedro Martinez 7-6 (7-2) 1-6 6-3.

Diego Schwartzman will take on Grigor Dimitrov in the second round. The Argentine 13th seed beat Benoit Paire 6-2 6-7 (5-7) 6-1, while Dimitrov overcame Maxime Cressy 6-2 7-6 (7-4).

Cristian Garin was on the end of a shock thrashing by Denmark's Holger Rune in the first round of the Serbia Open on Monday.

The Chilean fifth seed, who was the highest-ranked player in action, is regarded as one of the ATP Tour's best on clay but hardly got a look-in as 18-year-old Rune emerged with an impressive 6-3 6-1 win.

Rune has risen to a career-high 72 in the ATP rankings and showed every sign that he will continue to climb over the season as he produced an aggressive performance that saw him take six of 17 break points.

Playing in only his fifth ATP Tour match on clay, Rune needed just an hour and 25 minutes to see off Garin – the winner of five tour-level titles on the surface – and set up a second-round clash with either Dusan Lajovic or Taro Daniel.

Sixth and seventh seeds Fabio Fognini and Miomir Kecmanovic avoided similar shocks, though their respective wins were wildly different.

Kecmanovic crushed veteran Richard Gasquet 6-0 6-3, while Fognini was forced to overturn a one-set deficit in his defeat of fellow Italian Marco Cecchinato 6-7 (5-7) 6-2 6-2.

No seeds were in action at the Barcelona Open, but Italian prospect Lorenzo Musetti enjoyed a hard-fought 7-5 7-5 defeat of Argentina's Sebastian Baez to seal his spot in the second round.

The 20-year-old is now 5-2 for the clay season and will go up against Dan Evans next. Joining Musetti in progressing is another promising youngster in Brandon Nakashima, who beat Nicolas Alvarez Varona 7-6 (8-6) 6-3 to tee up a clash with number two seed Casper Ruud.

Mackenzie McDonald, Elias Ymer, Kwon Soon-woo and Federico Coria were among the other victors, while retiring 2004 champion Tommy Robredo bowed out with a 6-1 6-1 loss to Bernabe Zapata Miralles.

Jannik Sinner saved multiple match points for the second straight match on Sunday, advancing to the last-16 at the Miami Masters.

After saving three in his opening match against Emil Ruusuvuoiri, the 20-year-old Italian denied Pablo Carreno Busta five times to eventually win 5-7 7-5 7-5.

A Miami finalist in 2021, the Italian was 5-4 down in the second set before winning 11 consecutive points to force a third frame.

Down a break before breaking-to-love in the third, Sinner was fearless with his ground strokes with the game on the line, moving to 5-0 in deciding sets for 2022.

He will face Nick Kyrgios, who continued his strong start to the year with a 6-2 6-4 win over Fabio Fognini.

Taking only 61 minutes to advance after defeating world number seven Andrey Rublev in straight sets in his opening match, Kyrgios hit 24 winners and only lost eight points on serve.

The Australian wildcard and Sinner were supposed to meet at Indian Wells earlier this year, but the latter had to withdraw due to illness.

Fellow unseeded Australian Thanasi Kokkinakis advanced past Denis Kudla, while Francisco Cerundolo upset Gael Monfils.

In the late result on Sunday, Alexander Zverev was a comfortable 6-2 6-2 winner over Mackenzie McDonald.

The German second seed put McDonald under immediate pressure with his return of service, winning 13 of 22 points on the American's second serve.

Meanwhile, Cameron Norrie and Casper Ruud saw their way through in straight sets.

Wild card Nick Kyrgios admitted he was "pretty good" as he won in the opening round at the Indian Wells Masters over Sebastian Baez on Thursday.

The Australian cruised past Baez in one hour and 12 minutes, winning 6-4 6-0 to secure a second-round meeting with another Argentine, 32nd seed Federico Delbonis.

Kyrgios, who had not competed since January's Australian Open, was full of his typical flair, highlighted by 27-15 winners and 12-1 aces.

"When I play good, I'm pretty good," Kyrgios said after the match. "I'm just going back to basics."

Fabio Fognini made history in his 3-6 6-3 6-3 victory over Pablo Andujar, with his 392th career ATP win clocking up the most ever for an Italian, surpassing Adriano Panatta.

Compatriot Lorenzo Musetti also progressed on Thursday with a 6-3 7-5 win over American Marcos Giron.

Rising American talent Jenson Brooksby defeated Roberto Carballes Baena 6-1 6-4, while countryman and wild card Jack Sock brushed aside Juan Manuel Cerundolo 6-1 6-1 in little over an hour.

Pedro Martinez made light work of Joao Sousa 6-4 7-5, while Tomas Machec got past Alexei Popyrin 6-3 7-5.

Diego Schwartzman felt he played "an almost perfect match" to overcome Pedro Martinez in straight sets and reach the quarter-finals of the Rio Open.

The third seed advanced with a 6-1 6-1 victory, though that does not quite tell the whole story as the second game of the first set lasted a mammoth 24 minutes and 40 seconds.

Martinez saved eight break points in that lengthy game before finally being outdone by Schwartzman, who will now face another Spaniard in Pablo Andujar.

Incredibly, Martinez won 31 points in the first set but just one game.

"It was unbelievable," Schwartzman said. "This was probably the longest game in the history of the tournament 

"I don't remember anything like this before. I played an almost perfect match, I played against an opponent that had as much confidence as me."

Andujar beat Albert Ramos-Vinolas 7-5 5-7 6-3, while fourth seed Pablo Carreno-Busta lost 5-7 6-4 6-3 to Fabio Fognini in the shock of the day.

Federico Coria awaits Fognini after following up his surprise win over defending champion Cristian Garin with a 7-6 (7-2) 4-6 6-4 victory against Fernando Verdasco.

At the Delray Beach Open, top seed Cameron Norrie beat Oscar Otte 6-3 7-5 and will face Sebastian Korda, who saw off Andreas Seppi 7-5 6-3, for a place in the semi-finals.

Tommy Paul and Stefan Kozlov are also through to the final eight in Florida after beating Denis Istomin and Steve Johnson respectively in straight sets.

Jenson Brooksby made a winning start to his 2022 season on the ATP Tour as he reached the quarter-finals of the Dallas Open.

Last year's ATP Newcomer of the Year missed the Australian swing after testing positive for COVID-19 and only made his return at the Columbus Challenger at the end of last month.

The world number 54 admitted to feeling a little nervous in his 6-3 3-6 6-3 win over Andreas Seppi, but he said: "I competed well. As an American in the U.S., it was a great crowd. I missed that atmosphere for a few months.

"I thought I stayed pretty calm out there; a good balance of calm and competing, which is always a focus of mine."

Fifth seed Adrian Mannarino enjoyed smoother progress into the quarter-finals, beating Yoshihito Nishioka 6-3 6-1.

Vasek Pospisil saved a match point before coming through 6-7 (3-7) 7-6 (8-6) 6-2 against Jurij Rodionov, setting up a last-eight clash with home favourite John Isner, whose compatriot Reilly Opelka also progressed from a big-serving contest with Cedrik-Marcel Stebe.

At the Argentina Open, Fabio Fognini progressed to his first Tour-level quarter-final since April after battling past Pedro Martinez.

The Italian won 6-4 7-6 (7-5) to secure a meeting with Federico Delbonis, the Argentine having dispatched Pablo Andujar in straight sets.

Delbonis' compatriot Diego Schwartzman also defeated Spanish opposition in the form of Jaume Munar, although the world number 15 was made to work hard for a victory that sent him into a last-eight contest with Francisco Cerundolo.

Schwartzman came through 7-6 (7-2) 7-6 (7-4) in two hours and 23 minutes, eventually closing out the victory with a return winner on his seventh match point.

"I'm very happy because it was tough at the end," Schwartzman said. "He was saving too many match points, winning too many good points at the end of the match and he had the chance to go into the third.

"I think the tie-break, in the beginning, I played better than him. But at the end, he was fighting and he was there."

Alexander Zverev overcame former world number one Andy Murray to reach the Indian Wells Masters last 16 as Stefanos Tsitsipas also progressed, but Matteo Berrettini lost.

Olympic Gamed gold medallist and third seed Zverev fell behind a break in both sets but battled past Murray in straight sets at the ATP Masters 1000 tournament on Tuesday.

Tsitsipas – the second seed – rallied from a set down to vanquish Fabio Fognini in the desert, while fifth seed Berrettini was a third-round casualty.

 

ZVEREV CLAIMS COVETED SCALP OF MURRAY

Having already defeated Novak Djokovic, Rafael Nadal and Roger Federer in his career, all that was missing for Zverev was a win over Murray to complete the 'Big Four' sweep.

Zverev added Murray to his list of scalps with a 6-4 7-6 (7-4) victory to reach the Indian Wells fourth round for the first time since 2016.

The German star has now won 19 of his last 20 matches since Wimbledon.

"He's the only one of the Big Four that I hadn't beaten yet, so I'm happy that I've done it today," said Zverev, who will clash with 14th seed Gael Monfils in the next round. "Obviously it was a fantastic match.

"I thought Andy played extremely well, maybe as well as he's played since the surgery. I hope he continues playing the same way, because tennis did miss him for a long time and I think it's good to have him back."

 

TSITSIPAS FIGHTS BACK

It was far from easy for Greek star Tsitsipas, who prevailed 2-6 6-3 6-4 against 25th seed Fabio Fognini.

Tsitsipas added to his ATP Tour-leading haul of match wins this season, which now stands at 53 after Fognini had been looking to score his first victory over the French Open runner-up.

Alex de Minaur – the 22nd seed – awaits after he took down 13th seed Cristian Garin 6-4 6-2 for his first trip to the Indian Wells last 16.

 

BERRETTINI BUNDLED OUT

Wimbledon finalist Berrettini was no match for Taylor Fritz, who surprisingly topped the Italian 6-4 6-3.

Berrettini entered the contest as the only player on the ATP Tour this season to register double-digit wins on three surfaces – 15-4 (hard), 13-4 (clay) and 11-1 (grass).

"We're coming to the end of the year, I could really use a big result," said Fritz after claiming his first top-10 win of the year. "This is just what I needed, playing one of my favourite tournaments close to home."

Andy Murray put his body to the test as the former world number one overcame teenage sensation Carlos Alcaraz at the Indian Wells Masters, where stars Stefanos Tsitsipas and Alexander Zverev advanced to the third round.

Murray needed more than three hours to see off 18-year-old talent Alcaraz, who announced himself on the big stage with a quarter-final run at the US Open.

An Indian Wells runner-up in 2009, Murray was joined in the next round by second seed Tsitsipas and third seed Zverev on Sunday.

 

MURRAY WINS BATTLE OF GENERATIONS

Injuries have struck down Murray in recent years, but the three-time grand slam champion showed there is still plenty of fight left in the tank after rallying past debutant Alcaraz 5-7 6-3 6-2.

Facing a player 16 years his junior, Murray – making his 13th Indian Wells appearance – reached the third round of an ATP Masters 1000 event for the first time since 2016.

The 34-year-old Murray, who hit an underarm ace, improved his record to 27-12 in the desert following three hours, four minutes on court.

"He's obviously got so much potential, so much firepower and these conditions it's not easy to finish points off quickly, but he's able to because he has so much pace from the back of the court so I had to fight extremely hard, coming back from a set down," said Murray, who will next meet Zverev. 

"I felt like in the second set he played maybe better. First set I felt like I had more of the opportunities but didn't get it so yeah, happy with the way I fought. He's a top-drawer young player."

 

ZVEREV QUALIFIES FOR TURIN AS TSITSIPAS CRUISES

US Open finalist and Olympic gold medallist Zverev outlasted talented American Jenson Brooksby 6-4 3-6 6-1 to set up a showdown with Murray.

World number four Zverev ended the contest with 12 aces and 28 winners, having qualified for next month's ATP Finals in Turin thanks to the German's four tour-level titles in 2021.

"It wasn't an easy match, but I'm happy to be through, I'm happy to be in the third round and playing Andy now," said Zverev, who has won 18 of his last 19 matches since Wimbledon. "I think he's the only one of the 'Big Four' [including Novak Djokovic, Rafael Nadal and Roger Federer] I haven't beaten yet, so I hope I can change that. I think it's incredible how well he's moving and incredible how well he's playing. I think he's very motivated so I hope I can show my best tennis."

It was far more routine for Greek star Tsitsipas, who eased past Pedro Martinez 6-2 6-4 in his tournament opener.

Tsitsipas needed just 93 minutes to take down his opponent for his Tour-leading 52nd win of the season as the French Open runner-up awaits 25th seed Fabio Fognini for a place in the fourth round.

 

BERRETTINI ROLLS ON AS AUGER-ALIASSIME SAYS GOODBYE

Italian fifth seed Matteo Berrettini won through to the third round via a 6-4 7-5 success against qualifier Alejandro Tabilo – his first Indian Wells win following two previous appearances.

Felix Auger-Aliassime was the biggest name to depart the event on Sunday, with the seventh seed and Flushing Meadows semi-finalist going down 6-4 6-2 to Albert Ramos-Vinolas.

Jannik Sinner, Pablo Carreno Busta, Cristian Garin and Gael Monfils were among the seeds to progress.

Brandon Nakashima has been one of the ATP Tour's hottest players throughout the hardcourt season, and he kept rolling Monday before a hometown crowd. 

The 20-year-old Nakashima rallied to defeat Italian veteran Fabio Fognini 6-7(5), 6-1, 7-5 in the first round at the San Diego Open, setting up a second-round matchup with top seed Andrey Rublev. 

After qualifying for the main draw at Wimbledon earlier this summer, Nakashima reached finals at Los Cabos and Atlanta in successive weeks, falling to John Isner in the latter finale. He then knocked Isner out of the US Open in the first round in straight sets. 

Monday, he won 80 per cent of the points on his first serve, dialling up eight aces to just one for Fognini, who also double faulted 11 times. 

Another Southern California native, Taylor Fritz, also advanced Monday, beating qualifier Salvatore Caruso 6-4 7-6 (2) to earn a second-round meeting with fourth seed Denis Shapovalov.

It was a welcome reprieve for the world number 39, who had lost five of his previous six matches dating to a quarter-final win over Reilly Opelka in Atlanta. 

Earlier, world number 24 Aslan Karatsev opened the day's action by defeating Federico Delbonis 6-1 7-5. 

Carlos Alcaraz, a 17-year-old wildcard, will face Rafael Nadal in the second round of the Madrid Open, with the top seeds set to get their campaigns underway on Tuesday and Wednesday.

Alcaraz, featuring in an ATP Masters 1000 event for just the second time, was in impressive form as he saw off France's Adrian Mannarino 6-4 6-0.

The teenager, who will face Nadal on his 18th birthday on Wednesday, fired 19 winners as he took the initiative against his more experienced opponent and his reward is significant.

He became the tournament's youngest ever match winner, beating the record set by Nadal.

"For me, [to] play against Rafa is a dream come true," Alcaraz said as he readies himself to go up against the 20-time grand slam winner.

"Since I was a kid, I wished to play a match against Rafa and now I will be able to here [on] the Centre Court of La Caja Magica in Madrid. It is a really special match against Rafa."

He told Tennis Channel: "It's the best present for my birthday."

The biggest casualty of the day was 13th seed Grigor Dimitrov, who lost 3-6 6-3 7-6 (7-5) to Lloyd Harris early on, the South African now 4-0 against top-20 opponents this year.

Two qualifiers in Pablo Andujar and Marcos Giron played out a remarkable encounter that lasted three hours and 21 minutes.

The first set alone clocked in at just over an hour and a half, but eventually Giron came through the gruelling clash 6-7 (8-10) 7-6 (7-4) 7-5 to set up a meeting with third seed Dominic Thiem.

Fabio Fognini defeated Carlos Taberner 7-6 (7-4) 2-6 6-3 for the right to face eighth seed and Italian countryman Matteo Berrettini.

Diego Schwartzman, the seventh seed, awaits Aslan Karatsev after he beat Ugo Humbert in straight sets in what was the Russian's debut appearance at the tournament.

Dan Evans and John Isner were among the other players to secure progress on Monday.

Rafael Nadal was dumped out of the Monte Carlo Masters as Andrey Rublev completed a superb 6-2 4-6 6-2 victory in their quarter-final clash.

Nadal went into the meeting with a 73-5 record at the event but Russian Rublev was in inspired form to stun his Spanish opponent.

The 11-time champion looked set to complete a trademark comeback after taking a 74-minute second set, yet Rublev held firm in the decider to claim a memorable victory after two hours and 33 minutes on court.

"I cannot imagine being in the situation of Rafa, knowing that you are the best player on clay and you have that pressure every time," Rublev said, according to the ATP Tour website.

"I think for him it must be incredibly tough every time. I am in shock [with] the way he is playing under this pressure and that is why he is a legend."

Rublev will face Casper Ruud in Saturday's semi-final after he overcame defending champion Fabio Fognini 6-4 6-3.

Dan Evans followed up his superb victory over Novak Djokovic on Thursday with a slender win over David Goffin to reach his first Masters 1000 semi-final.

World number 33 Evans, who had come into the tournament having lost his previous 10 matches on clay, overcame Goffin 5-7 6-3 6-4 in two hours and 42 minutes.

"I am proud of how I came back today, especially with what happened in the first set," he said after the match.

"I felt my concentration wasn't great and I am really happy with coming through. Yesterday would not have been worth it with a bad performance today."

Evans will face Stefanos Tsitsipas, who progressed when opponent Alejandro Davidovich Fokina retired injured in their quarter-final.

Spaniard Davidovich Fokina did not return for the second set after earlier receiving treatment during the first, which Tsitsipas won 7-5.

Novak Djokovic will tackle teenage rising star Jannik Sinner for the first time in a tantalising clash of tennis generations on Wednesday at the Monte Carlo Masters.

World number one Djokovic is returning to action this week, having taken time away from the tour since banking an 18th grand slam title by winning the Australian Open in February.

He received a first-round bye, but waiting for him in the last 32 is Sinner, who on Tuesday saw off 2017 Monte Carlo runner-up Albert Ramos-Vinolas 6-3 6-4, again illustrating the 19-year-old Italian's great potential.

World number 22 Sinner is the only teenager ranked inside the top 80 in the men's game and is coming off his first run to a Masters final, at the Miami Open.

The switch from hard courts to clay is one that Sinner is having to deal with, and seeing off a specialist on the surface in round one represents an impressive start, although facing two-time former champion Djokovic will be a step up.

"It's always good for me to see what I can do on clay," Sinner said, quoted on the ATP website. "Obviously, I am not in the best form on clay now for the first week.

"But I think today was a solid match from my side. It was not easy. He's not giving [away] one point, so you have to stay there the whole match. I think I played a good match from my side."

Greek fourth seed Stefanos Tsitsipas reached the last 16 with a 6-3 6-4 win over Russian Aslan Karatsev, but there was disappointment at the same stage for Italian eighth seed Matteo Berrettini, beaten 7-5 6-3 by Spain's Alejandro Davidovich Fokina. Those were the only second-round matches of the day.

Surprise Miami champion Hubert Hurkacz made a winning start, battling to a 6-3 3-6 6-3 first-round success against Italian qualifier Thomas Fabbiano to reach round two.

Roberto Bautista Agut, Grigor Dimitrov, Pablo Carreno Busta and Fabio Fognini each booked places in round two thanks to straight-sets wins.

Qualifier Federico Delbonis was a 7-5 6-1 victor over France's Adrian Mannarino, meaning the Argentinian faces the ultimate test in clay-court tennis next, a tussle with Rafael Nadal, the 11-time former champion in Monte Carlo.

Nadal has won all four of their previous matches, and their fifth encounter will immediately follow the Djokovic-Sinner match on Wednesday.

Top seed Stefanos Tsitsipas and fellow star Alexander Zverev progressed to the Mexican Open quarter-finals on Wednesday, but Milos Raonic bowed out.

Tsitsipas was too good for big-serving American John Isner in a 6-3 6-2 victory in Acapulco midweek.

A two-time Australian Open finalist, having also reached the French Open final four last year, Tsitsipas excelled on serve against Isner.

Greek star Tsitsipas only dropped one point on his first serve – not facing a break point throughout the last-16 contest – while firing down eight aces.

Standing in the way of Tsitsipas and a semi-final spot at the ATP 500 tournament is Canadian sensation Felix Auger-Aliassime.

In a battle of the NextGen, seventh seed Auger-Aliassime saved four of five break points in a 6-3 6-4 win over wild card Sebastian Korda.

Zverev will feature in his third Mexican Open quarter-final in four years after the second seed took down Laslo Djere 6-4 6-3.

Runner-up in 2019, Zverev will next face eighth seed Casper Ruud – who topped Tallon Griekspoor 4-6 6-3 7-6 (7-3) in the quarters.

"I think today what showed the most is that I got better with the match," Zverev said. "I started off extremely sloppy, started off with a lot of unforced errors.

"The longer the match went on the better I started playing and this is something that is very important for me. When I get into a rhythm I feel very comfortable on court and that's how I felt today."

Elsewhere, Lorenzo Musetti's giant-slaying run continued following a 2-6 6-3 7-6 (7-1) victory against Frances Tiafoe.

Musetti earned his first ATP 500 quarter-final as the Italian prepares to meet fifth seed Grigor Dimitrov, who eased past Miomir Kecmanovic 6-4 6-2.

There was an upset after fourth seed Raonic crashed out 6-4 6-2 at the hands of Dominik Koepfer, while sixth seed Fabio Fognini lost 6-4 6-3 against Cameron Norrie.

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