Arizona Cardinals star Kyler Murray said he enjoyed a "little more freedom" in the absence of Kliff Kingsbury after the NFL's hottest team preserved their perfect start to the season.

Kingsbury missed Sunday's clash against the Cleveland Browns after testing positive for coronavirus, but the high-flying Cardinals – the only undefeated franchise remaining – still won 37-14 to improve to 6-0.

Defensive co-ordinator Vance Joseph and assistant head coach/special teams co-ordinator Jeff Rodgers stepped up to share responsibilities in Kingsbury's absence, while assistant wide receivers coach Spencer Whipple was calling plays in Murray's ear.

Murray was 20-of-30 passing for 229 yards and four touchdowns as the Cardinals won six straight games for the first time since Weeks 7-16 of the 2015 season.

"I think once we got the news, it was just an opportunity," Cardinals quarterback Murray said post-game.

"Kind of exciting to go prove ourselves on the road against a great team. I think you could feel the energy before the game."

"That may be a product of not having a coach out there, just having a little more leeway," Murray said after becoming the first Cardinals QB since 1950 with a 100-plus passer rating in five of the team's first six games of a season.

"I guess that did give me a little more freedom, just to whatever I did see, go with it and that's what Whipple's saying to me the whole time: 'Whatever you see'. And I stick to that same rule, as long as it makes sense. You got a plan and go with it."

The Cardinals are 4-0 on the road and have won each game by no fewer than 12 points – in their franchise history, Arizona had never won four consecutive away games by double digits.

On Kingsbury's absence, stand-in coach Joseph added: "It was really seamless".

"It's been an up and down week, but our team leaders were great all week," Joseph said. "No one wavered, no one blinked. The staff didn't blink. Every day it was bad news and no one blinked - not one time. Even yesterday. Even Saturday morning at practice when the players knew that Kliff was down for the game, there were no worries.

"There was really an excitement to go play a really good football team. The boys performed. This staff is amazing. It's a great football staff. It's our third year all together and that helps - having continuity like this."

Baker Mayfield's troublesome left shoulder popped out of joint twice during the Cleveland Browns' 37-14 NFL loss to the Arizona Cardinals on Sunday, but the quarterback "absolutely" expects to face the Denver Broncos in Week 7.

Mayfield initially injured his non-throwing shoulder against the Houston Texans on September 19, suffering a partially torn labrum, and the Browns star has worn a brace in subsequent games. 

That extra protection could not save him when Arizona's J.J. Watt hauled him to the ground in the third quarter, forcing a fumble and leaving Mayfield on the ground in pain. 

But Mayfield returned to the game when the Browns got the ball back and finished 19-of-28 passing for 234 yards with two touchdowns and an interception. 

Case Keenum finished the game at quarterback for Cleveland once the score got out of hand, but Mayfield said he was confident he would be cleared to play the Broncos on Thursday, despite meeting the media with his left arm in a sling. 

"It feels like s***," he said of his shoulder, adding: "It dislocated again [on the Watt sack] and then slipped out again on a non-contact play, so just got to figure out a way to get better."

Mayfield was sacked five times as the Browns played without their usual starting tackles Jedrick Wills Jr. and Jack Conklin. 

"It was just one of those days," Mayfield said. "We couldn't get things going, they had a good plan for us and we got punched in the mouth."

Mayfield and the Browns will have to recover quickly as they face what has become a critical game against the Broncos.

Cleveland entered the year fancied as possible Super Bowl contenders and suffered a tough season-opening loss to reigning AFC champions the Kansas City Chiefs before reeling off three straight wins. 

The Browns now sit at 3-3 after a wild loss to the Los Angeles Chargers in Week 5 and Sunday's blow-out defeat. 

"We're going to see what we're made of," Mayfield said. "Our backs are against the wall. I like our chances."

The Cowboys came from behind twice in the fourth quarter to force overtime before Dak Prescott's touchdown pass in the extra session gave Dallas a 35-29 victory over the New England Patriots on Sunday. 

Prescott hit a wide-open CeeDee Lamb from 35 yards out with just under four minutes to play in overtime for the victory, the final strike in a game that saw the Dallas quarterback complete 36 of 51 passes for 445 yards and three TDs. 

The final touchdown capped a wild final few minutes in Foxborough, where Trevon Diggs momentarily stunned the New England crowd by intercepting rookie quarterback Mac Jones and returning it 42 yards for a score to give Dallas a 26-21 lead with 2:27 remaining in the fourth quarter. 

Diggs has intercepted a pass in every game this season, with seven picks overall, and has returned two of them for touchdowns. He is the first NFL player in the Super Bowl era (since 1966) to intercept at least seven passes with multiple touchdowns in his team's first six games of the season. 

But Jones answered on the very next play, hitting Kendrick Bourne for a 75-yard touchdown and passing for the two-point conversion to give New England a 29-26 lead with 2:11 to play. 

That was too much time to leave Prescott, though, and he drove the Cowboys (5-1) downfield to set up kicker Greg Zuerlein – who had missed from 51 yards minutes earlier – for a 49-yard field goal that sent the game to overtime. 

After the Dallas defence forced New England (2-4) to punt in the first possession of overtime, Prescott completed all five of his pass attempts on the game-winning drive. 

The Cowboys racked up 567 yards of total offence on the day, the first time the Patriots allowed at least 500 yards in a game since surrendering 538 to the Philadelphia Eagles in losing Super Bowl LII four years ago. 

Murray, Cardinals stay unbeaten

Kyler Murray threw four touchdown passes as the Arizona Cardinals remained the NFL's only unbeaten team with a 37-14 rout of the Cleveland Browns. 

Murray completed 20 of 30 passes for 229 yards and did not throw an interception as Arizona – without head coach Kliff Kingsbury due to COVID-19 – built a 20-0 lead, then saw Cleveland come back before half-time before pulling away after the interval. 

Baker Mayfield tossed a pair of touchdowns in the final 5:06 of the opening half before suffering a shoulder injury as the Cardinals' defence held Cleveland scoreless after the break on the way to their first 6-0 start since 1974.

In Denver, the Las Vegas Raiders held off the Broncos 34-24 in Rich Bisaccia's first game as interim head coach after Jon Gruden's resignation Monday. 

The unbeaten Arizona Cardinals will be without head coach Kliff Kingsbury on Sunday after he tested positive for coronavirus.

Arizona announced on Friday that Kingsbury had contracted COVID-19, ruling him out of the NFL clash with the Cleveland Browns.

Cardinals quarterbacks coach Cam Turner and defensive tackle Zach Allen will also be sidelined against the Browns following positive tests.

Defensive co-ordinator Vance Joseph and assistant head coach/special teams co-ordinator Jeff Rodgers will share head coach responsibilities in Kingsbury's absence.

The Cardinals lead the NFC West and are the NFL's lone undefeated team at 5-0 as they look to stay perfect this week.

This is the fifth time the Cardinals – an original NFL franchise – have won their first five games but first time since moving to Arizona. They did it twice as the Chicago Cardinals (1922 and 1923) and twice as the St Louis Cardinals (1966 and 1974), per Stats Perform.

Arizona quarterback Kyler Murray has attempted at least 30 passes and completed more than 70 per cent of them in each of his last four games – that matches the longest such streak by a Cardinals player over the last 60 seasons. Kurt Warner had a four-game streak of that kind in 2008.

On the list of teams built to potentially end the Arizona Cardinals' unbeaten start to the season, the Cleveland Browns are near the top.

However, the Browns are tasked with dealing the Cardinals their first loss of the season without their best offensive player, with running back Nick Chubb ruled out because of a calf injury.

That blow robs the Browns of a runner who is second only to Tony Pollard of the Dallas Cowboys (6.37) in yards per attempt among running backs with 5.81 and is also second with 14 runs of 10 yards or more through five games of the 2021 campaign.

Second to Pollard (4.56) among backs with at least 10 attempts in yards per carry on plays where a defender disrupts the run, Chubb (4.21) stands as arguably the elite running back in the NFL, his remarkable blend of vision, elusiveness, power and speed helping establish him as the focal point of Cleveland's attack.

Yet they may still be able to succeed against the Cardinals' defense without Chubb in their backfield.

While the Cardinals have done an excellent job keeping opponents out of the endzone – their 82 offensive points allowed are the third-fewest in the league – they have struggled to contain opposing running backs.

Arizona's defense has allowed an opponent rushing average of 5.39 yards per carry; only the Los Angeles Chargers (5.59) have performed worse in that regard.

And the Browns do have an extremely reliable reserve to call upon to take advantage of that weakness.

Kareem Hunt is averaging 5.36 yards per carry and, reflecting his ability to stay on his feet through attempted tackles, leads all backs with at least 10 carries with 3.10 yards after contact per rush.

Cleveland's success on the ground is a testament to the strength of their offensive line.

Every member of the Browns' starting offensive line has a double-team adjusted run-block win rate of at least 79 per cent, though tackles Jedrick Wills and Jack Conklin are both questionable for Sunday.

Conversely, only three members of Arizona's defensive front have a double-team adjusted run defense win rate above 30 per cent.

In other words, the Browns have a clear matchup advantage in the run game and, even without Chubb, have a back with the ability to exploit it.

Cleveland's run game made a huge contribution to them scoring 42 points in a losing effort against the Chargers last week. With MVP candidate Kyler Murray helming an often explosive offense, they may need a similar showing this week to improve to 4-2. Thankfully, Hunt is more than capable of delivering such a performance. 

The Philadelphia Eagles have traded three-time Pro Bowler Zach Ertz to the Arizona Cardinals.

The 30-year-old tight end forged what the team described as a "special legacy" in an eight-year spell in Pennsylvania that included winning Super Bowl LII.

Ertz joined the Cardinals in exchange for a fifth-round draft pick in 2022 and rookie cornerback Tay Gowan, it was confirmed on Friday.

Ertz's defining moment for the Eagles came in the Super Bowl defeat of the New England Patriots three years ago, his 11-yard catch and drive for the end zone late in the fourth quarter helping to secure a 41-33 victory.

A second-round pick in 2013, Ertz made an NFL-record 116 receptions in 2018 and is second only to Harold Carmichael for catches in Eagles history, making 579 in the regular season and 33 in the playoffs.

He signed off in style on Thursday, scoring a touchdown in the 28-22 loss to the Tampa Bay Buccaneers at Lincoln Financial Field in what proved to be his final appearance for the franchise.

"Zach Ertz built a special legacy in Philadelphia," said chairman and CEO Jeffrey Lurie. "Talented, tough, and passionate, he helped to establish our team's culture and played a vital role in our success over the years.

"Zach created so many memories that will live on forever, from setting numerous franchise and league records, to reaching across the end zone for the game-winning touchdown in our first-ever Super Bowl Championship. He will always be a member of the Eagles family, not only because of what he accomplished on the field, but also because of the wonderful person, dedicated leader, and exemplary role model that he was for nine seasons in Philadelphia. We wish Zach and [wife] Julie nothing but the best."

The Cardinals, top of the NFC West after a 5-0 start, welcomed Ertz as a "talented replacement" for Maxx Williams, who is out for the rest of the season with a knee injury.

The Green Bay Packers head into Week 6 on the back of a remarkable overtime victory over the Cincinnati Bengals last time out.

Mason Crosby was the hero with a match-winning field goal, though his successful punt came on the back of three misses, not to mention the Bengals' Evan McPherson twice clipping the post with efforts in both regulation time and overtime.

The win took the Packers to 4-1 for the season, and next up are old rivals the Chicago Bears on Sunday. 

Meanwhile, the Baltimore Ravens (also 4-1) will look to build on their Lamar Jackson-inspired comeback against the Indianapolis Colts on Monday by beating the similarly in-form Los Angeles Chargers, and the Arizona Cardinals will look to continue their perfect start to the season as they travel to Cleveland.

 

Green Bay Packers @ Chicago Bears

One of the fiercest rivalries in the NFL rears its head in Week 6, with Green Bay travelling to Chicago. The foes share 22 championship titles between them, and this divisional contest in the NFC North is sure to serve up a treat.

The Packers are 21-5 in regular-season games against the Bears since 2008, when Aaron Rodgers became Green Bay's starting quarterback - indeed, Rodgers has started 25 of those meetings and is 11-2 in the 13 games he has started against Chicago since 2014, throwing 33 touchdown passes and no interceptions in 11 wins. There are three other matchups in which one team has beaten the other 21 times since 2008: Baltimore over the Cleveland Browns (22-4) and the New England Patriots over the New York Jets (22-5) and the Buffalo Bills (21-5).

This is the Packers' first road game against a division rival this season. Green Bay won all three of their away games against NFC North rivals in each of the past two campaigns.

Chicago are 3-2 for the season, though they have a league-low 728 passing yards. The Saints, with 904, are the only other team below 1000. If the Bears are to get anything from this game, they may well rely on the defensive prowess of Khalil Mack, who led the team with seven tackles in Week 5's 20-6 win over the Las Vegas Raiders.

Rodgers will be looking to pick out Davante Adams, meanwhile. He caught 11 passes for 206 yards in the win in Cincinnati. It was the third time since 1997 that a Packers player had 200 or more receiving yards in one game. 

Los Angeles Chargers @ Baltimore Ravens

This will be the first meeting between the Chargers and Ravens since the 2018 Wild Card round – Los Angeles claiming a 23-17 win on that occasion.

The Ravens are 3-1 in the regular season at home against the Chargers, though the last three games have been decided by seven points total. Baltimore go into the game on the back of a brilliant comeback win over the Colts. They trailed by 19 points with less than one minute remaining in the third quarter but came back to win 31-25 in overtime - their largest second-half comeback victory in franchise history.

Quarterback Jackson threw for 335 of his 442 passing yards in the second half and overtime, while completing 90.6 per cent of his passes (29/32). Over the last 30 seasons, there have been 635 quarterbacks to attempt at least 30 passes in the second half/OT of a game – he is the only one with a completion percentage over 90 per cent.

Los Angeles QB Justin Herbert, meanwhile, accounted for five touchdowns (four passing, one rushing) along with 427 total yards in just his 20th career start in the Chargers' 47-42 win in Cleveland. For any quarterback in his first 20 career starts, Herbert ranks first in completions (535), second in pass yards (5912) and third in total touchdowns (50).

Arizona Cardinals @ Cleveland Browns

The Cardinals' dream start to the season continued with a 17-10 triumph over the San Francisco 49ers. Arizona is the only unbeaten team in the NFL. This is the fifth time the Cardinals, an original NFL franchise, have won their first five games but first time since moving from St. Louis in 1988.

Arizona have won their last four games against the Browns, dating back to 2007. Before this streak, they had never won more than two consecutive games versus Cleveland. The Browns lead the all-time series, 33 wins to 15, with three ties.

The Browns, however, have won their last six games against NFC teams, including wins against the Bears and Vikings this season. Cleveland’s last loss against an NFC opponent was to the Cardinals in Arizona in 2019 (38-24).

Cleveland's Nick Chubb has 4080 yards rushing in his 49-game NFL career, and will likely become the third active player who had at least 4000 rushing yards through his first 50 games in the NFL, joining Ezekiel Elliott (4881) and Le'Veon Bell (4225).

Elsewhere...

The Patriots have endured a difficult start for the season, going 2-3 through the opening five games. The 4-1 Cowboys are next up, though New England have history on their side, having won six straight games against Dallas, a run dating back to 1998.

London calls for the Miami Dolphins and Jacksonville Jaguars, as the Florida rivals go head-to-head at Tottenham Hotspur Stadium. The Jaguars' 37-19 loss at home to the Tennessee Titans last week extended their losing streak to 20 games. It is just the second 20-game losing streak in NFL history (the Tampa Bay Buccaneers lost 26 straight between 1976 and 1977).

It has been a difficult week for the Raiders, whose coach Jon Gruden resigned due to the emergence of offensive emails. Las Vegas take on the Denver Broncos, who they have more wins against than any other opponent in their history.

Cincinnati will look to bounce back from their defeat to the Packers when they take on Detroit. They have won six consecutive games against the Lions, going back to 1998, and a win on Sunday would see the Bengals equal a team record for the most successive victories against a single opponent, matching seven-game streaks against the Houston Oilers (1981- 1984) and the Browns (2014-2017).

Justin Herbert and the Los Angeles Chargers took another step in establishing themselves as NFL Super Bowl contenders as they pulled out a wild 47-42 victory over the Cleveland Browns.

The lead changed hands seven times as Herbert and Browns quarterback Baker Mayfield led their teams downfield almost at will, but the Chargers (4-1) scored last and the Browns (3-2) could not respond on Sunday.

Herbert continued building his MVP case as he went 26-of-43 passing for 398 yards and four touchdowns with no interceptions and ran for another score. 

The Chargers trailed 27-13 after a spectacular 52-yard touchdown run by Nick Chubb on the opening drive of the second half, but Herbert led them back to take a 28-27 lead and the teams exchanged touchdowns from there. 

Los Angeles thought they had tied the game when Herbert hit Austin Ekeler for a 19-yard touchdown with 3:15 to play but Tristan Vizcaino missed his second extra point of the game to leave the Chargers trailing by a point. 

The Browns went three and out on the next possession and Herbert led the Chargers to the three-yard line, where the Cleveland defence helped Ekeler cross the goal line on purpose with 1:31 to play so the Browns could get the ball back. 

But Mayfield could not finish the job, throwing three successive incompletions from the Cleveland 47-yard line to give the Chargers the ball and end the game. 

Murray, Cardinals remain unbeaten

The Arizona Cardinals improved to 5-0 and remain the only unbeaten team in the NFL after pulling out a 17-10 win against the San Francisco 49ers. 

Kyler Murray's explosive Arizona offence entered the game averaging 35 points per game but had to scrape out the win as they were out-gained 338 to 304 by Trey Lance and the 49ers (2-3). 

Murray completed 22 of 31 passes for 239 yards and a key nine-yard touchdown pass to DeAndre Hopkins with 5:13 to play that effectively put the game out of reach. 

Rookie quarterback Lance made his first start for San Francisco and completed just 15 of 29 passes for 192 yards with an interception, though he led all rushers in the game with 89 yards on the ground. 

Cowboys run away from battered Giants

The Dallas Cowboys took advantage of injuries to the New York Giants' two most important players on offence, rolling to a 44-20 home victory. 

The Giants lost quarterback Daniel Jones to a concussion and running back Saquon Barkley to an ankle injury and were outscored 27-7 after Graham Gano hit a field goal on the first drive of the second half. 

Dak Prescott completed 22 of 32 passes for 302 yards and three touchdowns for Dallas, while Ezekiel Elliott ran for 110 yards and a score. 

Star tight end George Kittle has been placed on injured reserve by the San Francisco 49ers.

On the same day he turned 28, the Niners confirmed their two-time All-Pro had been subject to the roster move due to an ongoing calf problem.

The decision means Kittle must miss at least three matches, including the upcoming NFC West divisional matchup at the undefeated Arizona Cardinals, a game for which he had initially been listed as doubtful.

San Francisco are already without quarterback Jimmy Garoppolo, who also has a calf problem, against the Cardinals, meaning rookie Trey Lance will start.

The team, who are 2-2 after losing two straight games, will hope Kittle is good to go again by Week 8 when they meet the Cardinals once more.

Kittle has struggled with his nagging injury for much of the 2021 season and has made just 19 catches for 227 yards, as he waits to score his first touchdown of the year.

He was restricted to just eight regular season games last year after suffering a broken foot.

Prior to those injury problems, Kittle had been utterly dominant in 2018 and 2019, helping the Niners to the Super Bowl in that period with 2,430 yards and 10 receiving TDs across 30 regular season games.

Kittle was a fifth-round draft pick ahead of the 2017 season.

Trey Lance will make his first start for the San Francisco 49ers against the Arizona Cardinals on Sunday.

Head coach Kyle Shanahan confirmed Lance would get the start after Jimmy Garoppolo again missed practice on Friday.

Garoppolo suffered a calf contusion during the first offensive series in San Francisco's 28-21 loss to the Seattle Seahawks last week.

He played the rest of the first half but was replaced by rookie third overall pick Lance for the second half.

Lance completed nine of his 18 passes for 157 yards and two touchdowns while rushing for 41 yards on seven carries.

San Francisco traded three first-round selections to move up from the 12th pick to the third pick in this year's draft for the right to take Lance and make him their quarterback of the future.

Sunday will provide his first opportunity to prove the 2-2 Niners were right to make that move across the course of a full game.

Inexperienced even at the college level, Lance played only one full season as a starter for North Dakota State in 2019, which saw him account for 42 total touchdowns and zero interceptions, with the COVID-19 pandemic limiting him to a one-game exhibition in 2020.

But Lance is undaunted by the challenge of stepping up to start at the highest level this early in his career against an undefeated Cardinals team.

"I feel very prepared. I really do. And I think that's a credit to the coaching staff and the guys around me," Lance told a media conference. 

"Those guys have made me feel very confident this week, and I feel confident in myself, just as I did going into the Seattle game, and just as I did every other week before this."

Lance is unlikely to have one of the 49ers' top offensive weapons available, with tight end George Kittle doubtful with a calf injury. Rookie running back Elijah Mitchell is set to return from a shoulder injury, meaning the running game will be almost exclusively in the hands of three rookies in the form of Lance, Mitchell and third-round pick Trey Sermon.

The Kansas City Chiefs will be out to burst the in-form Buffalo Bills' bubble when they meet in a standout NFL Week 5 showdown.

Buffalo stretched their winning run to three matches with a 40-0 rout of the Houston Texans last Sunday.

Week 4 was also one to remember for the Chiefs and particularly Andy Reid, who became the first coach in NFL history to win 100 games with two teams thanks to a 42-30 defeat of his former employers the Philadelphia Eagles.

As the only team with a perfect record, the Arizona Cardinals will look to make it 5-0 at the expense of the San Francisco 49ers.

Stats Perform previews the pick of the action in the next round of matches and the best of the rest.

 

Buffalo Bills @ Kansas City Chiefs

The Bills are sitting pretty at the top of the AFC East at 3-1, but they have lost five of their past six meetings against the Chiefs.

Buffalo will be on a revenge mission after they were beaten 38-24 by Kansas City in the AFC Championship Game last season, the largest margin of victory for the Chiefs in those five triumphs.

The Bills' thrashing of the Texans was the second time this season they have kept an opponent scoreless, having also done so against the Miami Dolphins in Week 2.

Reid's side prop up the AFC West with a 2-2 record, but their 18 touchdowns is more than any in the NFL and Josh Gordon will be hoping to add to that tally if he makes his debut.

San Francisco 49ers @ Arizona Cardinals

The Cardinals' dream start to the season continued with a 37-20 victory over the Los Angeles Rams in Week 4, taking them to 4-0 for only the second time since moving to Arizona nine years after they previously won their opening four games.

If recent history is anything to go by, there will not be much in their showdown this weekend, as four of the past five meetings between the two sides have been decided by only three points.

The 2-2 49ers travel to State Farm Stadium having come out on top in four of their previous four meetings, having lost their eight clashes beforehand.

Deebo Samuel caught a 76-yard touchdown pass in San Francisco's 28-21 loss to Seattle Seahawks in Week 4, making him the fourth 49ers wide receiver to have multiple receiving touchdowns of 75-plus yards in a single season – joining Torrey Smith, John Taylor, and Jerry Rice.

Cleveland Browns @ Los Angeles Chargers 

The Browns and the Chargers have made promising starts to the season and both come into the game on the back of wins that took them to 3-1.

Cleveland have not beaten the Chargers on the road since back in 1991, losing five on the spin since then – a run that is tied for their third-longest active road losing streak against an opponent (lost 17 straight in Pittsburgh and six straight at New England).

The past two games mark the first time the Browns have allowed seven points or fewer back-to-back since September 10-17, 1995. They have done so in three straight games only once in franchise history (in 1976).

Nick Chubb (388) and Kareem Hunt (355) are the second pair of running backs in the last 30 years to have 350+ scrimmage yards apiece over their team's first four games of a season. The other was the Chargers' Melvin Gordon III and Austin Ekeler in 2018. 

Elsewhere

Tom Brady broke Drew Brees' NFL passing yards record in the Tampa Bay Buccaneers' win over his former team the New England Patriots in Week 4 and could inflict more misery on the Dolphins this weekend. The legendary quarterback has thrown 67 touchdowns against Miami the third-most by a player against any opponent in the Super Bowl era (Dan Marino – 72 v. the New York Jets, Brady – 70 v. the Bills). 

The Green Bay Packers head to Cincinnati to do battle with the Bengals, who they beat 27-24 in their last encounter in 2017. That snapped a three-game winning streak by the Bengals in the series. The Packers' last win in Cincinnati came in Week 3 of the 1998 season.

Urban Meyer has come under fire for his night out after the Jacksonville Jaguars suffered a fourth loss from four last week and he really needs a win when the Florida team host the Tennessee Titans. Tennessee are 7-1 versus the Jaguars since 2017.

NFC East leaders the Dallas Cowboys will go in search of a fifth consecutive home win over the New York Giants.

The Arizona Cardinals are the last undefeated team left standing in the NFL after the Las Vegas Raiders were beaten on Monday.

There were five unbeaten franchises heading into Week 4 of the regular season, though one '0' was bound to go when the Cardinals travelled to the Los Angeles Rams, who had beaten reigning champions Tampa Bay in their previous outing.

However, Aaron Donald and the rest of the Rams defense could not slow down Arizona, who emphatically triumphed 37-20 on the road to take charge of the NFC West.

As for the others, the Denver Broncos went down at home to the Baltimore Ravens, while the Carolina Panthers lost in Dallas to the Cowboys.

With the Raiders unable to rally in the second half to overcome the Los Angeles Chargers, the Cardinals stand alone at 4-0 – and that is not their only impressive achievement.

They are the outright leaders in terms of winning percentage (1.000), but also total offense (440.5 yards) and scoring offense (35.0 points per game) as well. No team has topped all three categories through four weeks of a campaign since the Cleveland Browns in 1953.

However, head coach Kliff Kingsbury was clearly not getting too carried away by his team's start, as he made clear in the post-match media conference. Asked what he planned to do to celebrate beating the Rams, he replied: "Not so much. I'll watch Ted Lasso tonight and go to bed."

The play of Kyler Murray has been a key factor in the unbeaten run, the quarterback throwing for 1,273 yards, nine touchdowns and four interceptions. He has also ran for three scores, while his 76.1 completion percentage is the best in the NFL.

Murray's performances have not only led to Arizona winning four straight, but also pushed him to the front of the MVP race, albeit it is still only the early stages of the season.

The Cardinals are bidding to make the playoffs for the first time since 2015. They started the previous year with a 5-2 record, only to fall away after their bye week, losing six of their final nine games.

They face another stern test in Week 5, as they host divisional rivals the San Francisco 49ers (2-2).

Kyler Murray said the Arizona Cardinals are riding a wave of confidence after emerging as the NFC's lone unbeaten team following their win against the Los Angeles Rams.

The Cardinals improved to 4-0 for the NFL season thanks to a Murray-inspired 37-20 victory over the Rams in the battle of two undefeated franchises on Sunday.

Arizona quarterback Murray passed for 268 yards and two touchdowns, while running for 39 more yards as the Cardinals dismantled the Rams at Sofi Stadium, ending a run of eight straight defeats against a Sean McVay-coached team.

Murray became just the third player in the Super Bowl era with a 4-0 record, completion percentage of 75 or better and 1,200-plus passing yards in his team's first four games of a season, after Hall of Famer Peyton Manning and Seattle Seahawks star Russell Wilson.

"I was pretty confident coming into this game with the game plan we had, the week of practice we put together, probably the best game plan that I think personally that we've had since I've been in the league," Rams star Murray told reporters.

"With that, being confident in all the guys, this team, I was just confident in going out there and letting it ride. The guys did the same and I can't be more proud of them."

Murray added: "Not really too worried about what other people think. I think the guys in the locker room understand what we're doing, what we're capable of and where we can take it."

The Cardinals have not reached the playoffs since losing to the Carolina Panthers in the 2015 NFC Championship Game.

But, Arizona are attracting plenty of attention this season – the Cardinals have scored at least 30 points and had at least 400 yards of offense in every game.

"Not a statement," Cardinals head coach Kliff Kingsbury said. "We wanted to get a week better. Division games are important. We've got to continue to play physical football and clean some stuff up."

Russell Wilson produced a vintage performance to lead the Seattle Seahawks past the San Francisco 49ers 28-21.

Wilson celebrated his 100th NFL victory as the Seahawks (2-2) rallied past the 49ers (2-2) in San Francisco on Sunday.

The Super Bowl champion finished 16-of-23 passing for two touchdowns, while he rushed for another TD on four carries.

Wilson joined Hall of Famer Peyton Manning as the second quarterback in NFL history to win 100 games in their first 10 seasons.

The 49ers – with Jimmy Garoppolo starting under center – took an early 7-0 lead but that was as good as it got for San Francisco on home soil.

Wilson's 12-yard pass to DK Metcalf ensured the scores were tied at half-time before the former dominated in the third period – the eight-time Pro Bowler's 16-yard run putting the Seahawks 14-7 ahead and Freddie Swain then caught a throw to stretch the lead to 14 points.

Trey Lance – who completed nine of his 18 passes for 157 yards and two TDs – replaced Garoppolo (calf) in the second half and the rookie QB kept the 49ers in the contest with a monster 76-yard TD pass to Deebo Samuel during the closing stages of the third quarter.

After an Alex Collins touchdown gave the Seahawks a 28-13 lead early in the final period, Lance combined with Samuel again at the death, but it was too little, too late.

 

Cardinals stay unbeaten behind Murray

Kyler Murray inspired the high-flying Arizona Cardinals to a 37-20 win at the previously undefeated Los Angeles Rams.

Murray passed for 268 yards and two touchdowns, while running for 39 more yards as the red-hot Cardinals improved to 4-0 this season.

Meanwhile, Aaron Rodgers and Randall Cobb guided the Green Bay Packers to a third consecutive win – a 27-17 victory over the Pittsburgh Steelers.

Rodgers and Cobb connected for two touchdowns and ran for another score at home to the Steelers.

Packers superstar Rodgers threw his 420th career TD pass – tying Dan Marino for sixth all-time.

Under-fire Steelers QB Ben Roethlisberger threw his 400th career touchdown pass – the eighth player to do so.

Tom Brady is rarely not front and centre in the NFL, but it is particularly difficult to get away from football's GOAT this week.

Thursday marked the 20th anniversary of the quarterback's first NFL start. On Sunday, he needs only 68 yards to pass Drew Brees for the most passing yards in league history.

"It's definitely a special record because it speaks to the longevity that he's been able to experience and the level that he's been able to play at," Brees said at the start of the week.

Of course, that record will fall as Brady takes the Tampa Bay Buccaneers back to Foxborough to play the New England Patriots for the first time.

The seven-time Super Bowl champion made history time and again in 19 years with the Pats and does not look like stopping now in the pick of the Week 4 Sunday matchups, broken down by Stats Perform.

Tampa Bay Buccaneers @ New England Patriots

A win for the 2-1 Bucs would make Brady only the fourth starting quarterback to defeat all 32 NFL teams across their careers, joining Brees, Brett Favre and Peyton Manning.

The QB comes into this game in form, having thrown for at least 1,000 yards and 10 touchdowns through his team's first three games of the year for the second time, having also done so with New England in 2011. No other QB has achieved that feat twice.

The Pats will hope they have found a long-term successor in Mac Jones, whose 81 completions are the third-most by any QB in the Super Bowl era through three career games – after Joe Burrow (91) and Kyler Murray (84).

Tampa Bay have a poor record against New England, too. The Pats are 7-2 in this matchup all-time and have held the Bucs to 11.9 points per game – the fewest any current franchise has averaged against another.

Seattle Seahawks @ San Francisco 49ers

The Seahawks are in a spot of bother in the NFC West with a 1-2 record, but they are 14-3 over their past 17 games against the 49ers, making them the first team to beat San Francisco 14 times over a 17-game span since the Los Angeles Rams between 1973 and 1981.

Russell Wilson will hope his team-mates can catch up this week, having become the first QB in the Super Bowl era to complete at least 70 per cent of his passes for 250 yards and no interceptions in each of his first three games of a season. In fact, Seattle's back-to-back defeats marked the second time in franchise history they have lost consecutive games with no turnovers in either (also November 2008).

If nothing else, expect this game to be tight, with the 49ers' past seven games all decided by eight points or fewer – tying a franchise record – although San Francisco certainly have the talent to hurt the Seahawks.

The Niners have had touchdowns from 11 different players this year, tied for the most in NFL history through three games (also the 1964 Houston Oilers, 1987 Chicago Bears and 2002 Patriots). Deebo Samuel is the chief threat right now, though, with his 334 receiving yards the most by a 49er through three team games since Jerry Rice's 341 in 1995.

Arizona Cardinals @ Los Angeles Rams

The four NFC West teams are playing among themselves for the coming two weeks, meaning another mammoth matchup as the division's two 3-0 starters meet at SoFi Stadium in a series the Rams have dominated with eight straight wins against the Cardinals. That is their longest winning streak against a single opponent since a run of nine against the 49ers from 1976 to 1980.

A 4-0 start brings back contrasting memories for these two teams. The Rams made the Super Bowl after winning their first four in both 2018 and 2001, but the last time Arizona jumped out to such a start in 2015 they lost 11 of their remaining 12 games to finish 5-11.

Cardinals QB Murray makes for an entertaining watch, with at least one interception and one rushing TD in each of his first three games in 2021. It is only the third time a player has done that since 1960, with Murray accounting for one of the other two examples in 2020 (also Charlie Frye in 2006).

Crucially, Murray has more options through the air this year. Arizona have a league-leading six players with 10 or more receptions, having only had eight players reach that mark in the entirety of the 2020 campaign – tied for the fifth-fewest in the NFL.

Elsewhere...

The Kansas City Chiefs visit the Philadelphia Eagles looking to avoid losing three in a row for the first time since Patrick Mahomes became a starter. Back-to-back defeats to the Baltimore Ravens and the Los Angeles Chargers already represent the Chiefs' worst run since a pair of losses in Weeks 5 and 6 in 2019.

Dak Prescott is in top form as the Dallas Cowboys prepare to host the Carolina Panthers, but that game may be decided on defense. The Panthers have allowed a league-low 3.8 yards per play this season, while the Cowboys' 6.7 yards allowed per play is fewer only than the Chiefs (7.0) and the Minnesota Vikings (6.8).

The Denver Broncos have made the most of a kind schedule to join the Panthers at 3-0 but now face a first real test against the Ravens. Teddy Bridgewater will aim to maintain his high standards, having become the fourth player in the past 60 years to complete at least 75 per cent of his passes in the first three games of a season, along with Brady (2007), Brees (2018) and Philip Rivers (2020). Brady did so in four straight.

The Pittsburgh Steelers have won five consecutive regular season games against the Green Bay Packers going back to 1998, but veteran QB Ben Roethlisberger has made an unconvincing start to the campaign. He is one TD shy of 400 in the NFL – Aaron Rodgers was the seventh and most recent man to that mark.

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